Project name: Magnetic responsive scaffolds for stimulated bone regeneration,
Contract: no 97 din 01/10/2015
Project implementation: 01/10/2015-30/09/2017
Project code: PNII-RU-TE-2014-4-2534
Contracting authority: UEFISCDI
Project director: Irina Alexandra PAUN
Contract value: 550 000 lei
The main idea of MagReSSTiR project is to develop new types of 3D biomimetic, magnetic responsive scaffolds for bone repair and regeneration. The proposed concept will allow stimulated bone regeneration under remote controlled external magnetic field using magnetic responsive scaffolds with osteoconductive, osteoinductive and osteogenic characteristics similar to autogeneous bone grafts. Advanced laser micro- and nanofabrication technologies will be involved in building the biomimetic 3D architecture of the scaffolds. The magnetic field will stimulate the natural processes that regenerate and restore bone tissue to its functional state. A gradient deposition of nanocomposites employing hydroxyapatite, polymers, collagen and growth factors will help us to find the optimum ratio for which the osteogenesis will rise considerably. We also aim to get insight into the mechanisms of magnetic stimulated bone regeneration via in situ, in real time monitorization of the scaffolds/cells during the action of magnetic stimuli.
First stage (2015):
Develop scaffolds based on magnetic nanoparticles composite with a gradient concentration between osteoinductive and osteoconductive components
Value of the first stage: 58260.87 RON
Within this stage, we made the design for the 3D biomimetic architecture of the backbone structure of the scaffolds. Then, we proceeded to scaffolds fabrication, using the laser writing via two photons polymerization technique. Then, we optimized the gradient concentration between osteoinductive and osteoconductive components, which we used for coating the backbone structure of the scaffolds. Finally, we disseminated the results to the research community. The result of this stage consisted in magnetic responsive scaffolds with a gradient concentration between osteoinductive and osteoconductive components.
Second stage (2016):
Build and optimize scaffolds for magnetic stimulated bone-tissue regeneration
Value of the second stage: 291924.88 RON
Within this stage, we made the design and we implemented the magnetic stimulator. Then, we optimized the osteoconductive/osteoinductive ratios for scaffolds and their 3D biomimetic structure. Next, we performed in real-time optimization of magnetic stimulation, in the view of bone-tissue regeneration. Finally, we disseminated the results to the research community. The result of this stage consisted in optimized scaffolds based on magnetic nanoparticles nanocomposites, for magnetic stimulated bone-tissue regeneration