Project name: Magnetic responsive scaffolds for stimulated
bone regeneration,
MagReSSTiR
Contract: no 97 din 01/10/2015
Project implementation: 01/10/2015-30/09/2017
Project code: PNII-RU-TE-2014-4-2534
Contracting
authority: UEFISCDI
Project director: Irina Alexandra PAUN
Contract value: 550 000 lei
Project summary
The main idea of MagReSSTiR project is to develop new types
of 3D biomimetic, magnetic responsive scaffolds for bone repair and
regeneration. The proposed concept will allow stimulated bone regeneration
under remote controlled external magnetic field using magnetic responsive
scaffolds with osteoconductive, osteoinductive and osteogenic characteristics
similar to autogeneous bone grafts. Advanced laser micro- and nanofabrication
technologies will be involved in building the biomimetic 3D architecture of the
scaffolds. The magnetic field will stimulate the natural processes that
regenerate and restore bone tissue to its functional state. A gradient
deposition of nanocomposites employing hydroxyapatite, polymers, collagen and
growth factors will help us to find the optimum ratio for which the
osteogenesis will rise considerably. We also aim to get insight into the
mechanisms of magnetic stimulated bone regeneration via in situ, in real time monitorization of the scaffolds/cells during
the action of magnetic stimuli.
First stage (2015):
Develop
scaffolds based on magnetic nanoparticles composite with a gradient
concentration between osteoinductive and osteoconductive components
Value of the first stage: 58260.87
RON
Within this stage, we made the design
for
the 3D biomimetic architecture of the backbone structure of the scaffolds.
Then, we proceeded to scaffolds fabrication, using the laser writing via two
photons polymerization technique. Then, we optimized the gradient concentration between osteoinductive and
osteoconductive components, which we used for coating the backbone structure of
the scaffolds. Finally, we disseminated the results to the research community.
The result of this stage consisted in magnetic responsive scaffolds with a
gradient concentration between osteoinductive and osteoconductive components.
Second stage (2016):
Build
and optimize scaffolds for magnetic stimulated bone-tissue regeneration
Value of the second stage: 291924.88
RON
Within this stage, we made the design
and we implemented
the magnetic stimulator. Then, we optimized the osteoconductive/osteoinductive
ratios for scaffolds and their 3D biomimetic structure. Next, we performed in real-time
optimization of magnetic stimulation, in the view of bone-tissue regeneration.
Finally, we disseminated the results to
the research community. The result of
this stage consisted in optimized scaffolds based on magnetic nanoparticles
nanocomposites, for magnetic stimulated bone-tissue regeneration